Rivastigmine hydrogen tartrate, Acetylcholinesterase inhibitor (ab142540)

Overview

  • Product name

    Rivastigmine hydrogen tartrate, Acetylcholinesterase inhibitor
  • Description

    Acetylcholinesterase and butyrylcholinesterase inhibitor
  • Biological description

    Acetylcholinesterase and butyrylcholinesterase inhibitor. Reversibly forms covalent bonds with these enzymes. Parasympathomimetic or cholinergic agent. Active in vivo. Blood-brain barrier permeable.
  • Purity

    > 98%
  • CAS Number

    129101-54-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-3-[1-(Dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate tartrate
  • Molecular weight

    400.42
  • Molecular formula

    C14H22N2O2.C4H6O6
  • PubChem identifier

    14254240
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM, in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.C(C(C(=O)O)O)(C(=O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bailey JA  et al. Rivastigmine lowers Aß and increases sAPPa levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6:e21954 (2011). Read more (PubMed: 21799757) »
  • Ramírez-Expósito MJ  et al. Acetylcholinesterase inhibitor SDZ ENA 713 (Rivastigmine) increases brain pyrrolidone carboxyl peptidase activity. Eur Neuropsychopharmacol 11:381-3 (2001). Read more (PubMed: 11597825) »
  • Jann MW Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease. Pharmacotherapy 20:1-12 (2000). Read more (PubMed: 10641971) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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