Overview

  • Product name

  • Description

    Rabbit polyclonal to RIZ1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human RIZ1 aa 1250-1300 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    EDPLETSKEEEELNDSSEELYTTIKIMASGI KTKDPDVRLGLNQHYPSFKP


    Database link: Q13029

  • Positive control

    • Rat liver tissue; Rat brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab204110 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Predicted molecular weight: 189 kDa.
IHC-P 1/100 - 1/500.

When using a fluorescent probe the recommended dilution is 1/50-1/200.

Target

  • Function

    S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
  • Tissue specificity

    Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
  • Sequence similarities

    Contains 8 C2H2-type zinc fingers.
    Contains 1 SET domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • GATA-3-binding protein G3B antibody
    • HUMHOXY1 antibody
    • KMT8 antibody
    • Lysine N-methyltransferase 8 antibody
    • MTB-ZF antibody
    • MTE-binding protein antibody
    • PR domain containing 2, with ZNF domain antibody
    • PR domain zinc finger protein 2 antibody
    • PR domain-containing protein 2 antibody
    • PRDM2 antibody
    • PRDM2_HUMAN antibody
    • Retinoblastoma protein binding zinc finger protein antibody
    • Retinoblastoma protein-interacting zinc finger protein antibody
    • Retinoblastoma protein-interacting zinc-finger protein antibody
    • RIZ antibody
    • RIZ1 antibody
    • RIZ2 antibody
    • Zinc finger DNA binding protein antibody
    • Zinc finger protein RIZ antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat liver tissue tissue labeling RIZ1 with ab204110 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling RIZ1 with ab204110 at 1/200 dilution. The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated, used at 1/200 dilution for 40 minutes at 37°C. DAPI was used to stain the cell nuclei.

References

ab204110 has not yet been referenced specifically in any publications.

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