Overview

  • Product name

    RK-682, protein tyrosine phosphatase (PTP) inhibitor
  • Description

    Potent, selective and competitive protein tyrosine phosphatase (PTP) inhibitor
  • Biological description

    Potent, selective and competitive protein tyrosine phosphatase (PTP) inhibitor (IC50 values are 5.5, 54 and 2-11.6 μM at PTP1B, CD45 and VHR respectively). Inhibits cell cycle progression at G1/S transition.
  • Purity

    > 98%
  • CAS Number

    154639-24-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Saifudin A  et al. Protein tyrosine phosphatase 1B (PTP1B)-inhibiting constituents from the leaves of Syzygium polyanthum. Planta Med 78:1378-81 (2012). Read more (PubMed: 22763740) »
  • Sun Y  et al. In vitro reconstruction of tetronate RK-682 biosynthesis. Nat Chem Biol 6:99-101 (2010). Read more (PubMed: 20081823) »
  • Usui T  et al. Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition. Chem Biol 8:1209-20 (2001). Read more (PubMed: 11755399) »
  • Hamaguchi T  et al. RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. FEBS Lett 372:54-8 (1995). Read more (PubMed: 7556642) »

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