Overview

  • Product name
    Anti-RNase L antibody - N-terminal
    See all RNase L primary antibodies
  • Description
    Rabbit polyclonal to RNase L - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide within Mouse RNase L aa 139-167 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q05921

  • Positive control
    • Mouse liver cell lysate; mouse spleen cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab173102 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab173102 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 83 kDa.

Target

  • Function
    Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.
  • Tissue specificity
    Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
  • Involvement in disease
    Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the protein kinase superfamily.
    Contains 9 ANK repeats.
    Contains 1 KEN domain.
    Contains 1 protein kinase domain.
  • Domain
    The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.
    The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.
    The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity.
  • Cellular localization
    Cytoplasm. Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 5A dependent ribonuclease antibody
    • 2 5A dependent RNase antibody
    • 2' 5' oligoisoadenylate synthetase dependent antibody
    • 2-5A-dependent ribonuclease antibody
    • 2-5A-dependent RNase antibody
    • DKFZp781D08126 antibody
    • Interferon induced 2 5A dependent RNase antibody
    • MGC104972 antibody
    • MGC133329 antibody
    • PRCA 1 antibody
    • PRCA1 antibody
    • Ribonuclease 4 antibody
    • Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) antibody
    • Ribonuclease L antibody
    • Ribonuclease4 antibody
    • RibonucleaseL antibody
    • RN5A_HUMAN antibody
    • RNase L antibody
    • Rnasel antibody
    • RNS 4 antibody
    • RNS4 antibody
    see all

Images

  • Anti-RNase L antibody - N-terminal (ab173102) at 1/100 dilution + Mouse spleen cell lysate at 35 µg

    Predicted band size: 83 kDa

  • Anti-RNase L antibody - N-terminal (ab173102) at 1/100 dilution + Mouse liver cell lysate at 35 µg

    Predicted band size: 83 kDa

References

ab173102 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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