Principal Names – RNF13; RZF; ring finger protein 13; RING zinc finger protein.
Official Gene Symbol - RNF13.
GenBank Accession Number – NP_009213.
LocusLink ID - 11342 (human).
Gene Ontology terms - peptidase activity; proteolysis and peptidolysis; nucleus.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. This antibodoidy stained islets but not in ducts and acini of Human normal pancreas. However, in pancreatic ductal adenocarcinoma staining was in the ducts and acini.
Use at an assay dependent dilution. Detects a band of approximately 60 kDa (predicted molecular weight: 43 kDa).Can be blocked with Human RNF13 peptide (ab23020).
E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.
Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level).
The RING-type zinc finger domain is required for E3 ligase activity.
Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane. Lysosome membrane. Nucleus inner membrane. Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane.