Overview

  • Product name

    Anti-RNF144B antibody - N-terminal
  • Description

    Rabbit polyclonal to RNF144B - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Fusion protein corresponding to Human RNF144B (N terminal). The identity of the protein fusion partner is GST
    Database link: BC063311

  • Positive control

    • Human lung cancer and cervical cancer tissues
  • General notes

    Previously labelled as IBRDC2. 

Properties

Applications

Our Abpromise guarantee covers the use of ab197995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

Target

  • Function

    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
  • Tissue specificity

    Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Belongs to the RBR family. RNF144 subfamily.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • Domain

    The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis.
  • Post-translational
    modifications

    Auto-ubiquitinated.
  • Cellular localization

    Mitochondrion membrane. Cytoplasm. Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
  • Information by UniProt
  • Database links

  • Alternative names

    • bA528A10.3 antibody
    • E3 ubiquitin protein ligase RNF144B antibody
    • E3 ubiquitin-protein ligase RNF144B antibody
    • IBR domain containing 2 antibody
    • IBR domain containing protein 2 antibody
    • IBR domain-containing protein 2 antibody
    • IBRDC 2 antibody
    • IBRDC2 antibody
    • KIAA0161 antibody
    • MGC71786 antibody
    • OTTHUMP00000016079 antibody
    • OTTHUMP00000016080 antibody
    • OTTHUMP00000039360 antibody
    • p53 inducible RING finger protein antibody
    • p53-inducible RING finger protein antibody
    • p53RFP antibody
    • PIR2 antibody
    • R144B_HUMAN antibody
    • Ring finger 144B antibody
    • RING finger protein 144B antibody
    • RNF 144B antibody
    • RNF144B antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling RNF144B using ab197995 at 1/50 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling RNF144B using ab197995 at 1/50 dilution.

References

ab197995 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab197995.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up