Overview

  • Product name
  • Description
    Rabbit polyclonal to RNF23
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human RNF23 aa 247-277 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9HCM9

  • Positive control
    • MDA-MB435 cell line lysates and Human testis tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab172861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 60 kDa.
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    May facilitate apoptosis by inhibiting the poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.
  • Tissue specificity
    Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
  • Sequence similarities
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • Cellular localization
    Cytoplasm > cytosol. Mitochondrion. Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when co-localized with MOAP1.
  • Information by UniProt
  • Database links
  • Alternative names
    • HGNC:10065 antibody
    • MGC32984 antibody
    • RING finger protein 23 antibody
    • RNF23 antibody
    • Testis abundant finger protein antibody
    • Testis-abundant finger protein antibody
    • TFP antibody
    • TFP RING FINGER PROTEIN 23 antibody
    • TRI39_HUMAN antibody
    • Trim39 antibody
    • TRIM39B antibody
    • Tripartite motif containing 39 antibody
    • Tripartite motif-containing protein 39 antibody
    see all

Images

  • Anti-RNF23 antibody (ab172861) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

    Predicted band size: 60 kDa

  • Immunohistochemistry analysis of formalin-fixed paraffin-embedded Human testis tissue labeling RNF23 with ab172861 at 1/10 followed by peroxidase conjugation of the secondary antibody and DAB staining.

References

ab172861 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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