Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Western blot - Anti-RNF3 (247 aa isoform) antibody (ab3892)
ab3892 staining (1µg/ml) of Human Heart lysate (RIPA buffer, 30µg total protein per lane).Primary incubated for 1 hour.Detected by western blot using chemiluminescence. ab3892 staining (1µg/ml) of Human Heart lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.