Overview

  • Product name

    RO 20-1724, Phosphodiesterase 4 (PDE4) inhibitor
  • Description

    Selective phosphodiesterase 4 (PDE4) inhibitor
  • Biological description

    Selective cAMP-specific phosphodiesterase 4 (PDE4) inhibitor (IC50 = 3 μM). Centrally active in vivo.
  • Purity

    > 99%
  • CAS Number

    29925-17-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
  • Molecular weight

    278.35
  • Molecular formula

    C15H22N2O3
  • PubChem identifier

    5087
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC
  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:

  • Sharma V  et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav 101:239-45 (2012). Read more (PubMed: 22285388) »
  • Soderling SH  et al. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A 95:8991-6 (1998). Read more (PubMed: 9671792) »
  • Dent G  et al. Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol. J Pharmacol Exp Ther 271:1167-74 (1994). Read more (PubMed: 7996422) »

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