- References (8)
Product nameRo 25-6981 maleate salt, NR2B antagonist
- Ro25-6981 maleate salt
Potent, highly selective, activity-dependent blocker of NMDA receptors that contain the NR2B subunit (IC50 values are 0.009 and 52 μM at NR1C/NR2B and NR1C/NR2A, respectively). Displays no significant activity at kainate/AMPA receptors, Na+ and Ca2+ channels at concentrations showing maximal protection in neurotoxicity tests. Neuroprotective actions in vivo and in vitro.
Also available in simple stock solutions (ab146695) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.SMILESO=C(O)/C=CC(=O)O.Oc1ccc(cc1)[C@H](O)[C@@H](C)CN2CCC(CC2)Cc3ccccc3Source
This product has been referenced in:
- Chazot PL The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. Curr Med Chem 11:389-96 (2004). Read more (PubMed: 14965239) »
- Lynch DR et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol 416:185-95 (2001). Read more (PubMed: 11290368) »
- Fischer G et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 283:1285-92 (1997). Read more (PubMed: 9400004) »
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