Overview

  • Product name

    Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor
  • Description

    Selective cyclin-dependent kinase (Cdk1) inhibitor
  • Biological description

    Selective cyclin-dependent kinase (Cdk1) inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A, respectively). Enhances downstream p53 signaling. Induces G2/M-phase cell cycle arrest and apoptosis.
  • Purity

    > 99%
  • CAS Number

    872573-93-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • El Boustany C  et al. Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells. Cell Calcium 47:350-9 (2010). Read more (PubMed: 20172609) »
  • Kojima K  et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci 100:1128-36 (2009). Read more (PubMed: 19385969) »
  • Vassilev LT Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1. Cell Cycle 5:2555-6 (2006). Read more (PubMed: 17172841) »

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