Overview

  • Product name

    Ro 48-8071, 2,3-oxidosqualene cyclase (OSC) inhibitor
  • Description

    Potent 2,3-oxidosqualene cyclase (OSC) inhibitor
  • Biological description

    Potent 2,3-oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM). Displays lipid lowering activity. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    189197-69-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4-Bromophenyl)-[2-fluoro-4-[6-[methyl(prop-2-enyl)amino]hexoxy]phenyl]methanone
  • Molecular weight

    564.40
  • Molecular formula

    C23H27BrFNO2.C4H4O4
  • PubChem identifier

    1949
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Shenoy SD  et al. Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. Mol Pharmacol 65:1302-12 (2004). Read more (PubMed: 15102959) »
  • Peffley DM  et al. Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin. Biochem Pharmacol 56:439-49 (1998). Read more (PubMed: 9763219) »
  • Morand OH  et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res 38:373-90 (1997). Read more (PubMed: 9162756) »

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