Ro 61-8048, kynurenine 3-monooxygenase (KMO) inhibitor (ab141466)

Overview

  • Product name

    Ro 61-8048, kynurenine 3-monooxygenase (KMO) inhibitor
  • Description

    Potent, competitive kynurenine 3-monooxygenase (KMO) inhibitor
  • Biological description

    Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Orally active.

  • Purity

    > 98%
  • CAS Number

    199666-03-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Beconi MG  et al. Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos 40:2297-306 (2012). Read more (PubMed: 22942319) »
  • Zwilling D  et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell 145:863-74 (2011). Read more (PubMed: 21640374) »
  • Ouattara B  et al. Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias. J Mol Neurosci 38:128-42 (2009). Read more (PubMed: 18704766) »

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