Overview

  • Product name

    Rocaglamide, inhibitor of NF-kappaB activation
  • Description

    Potent inhibitor of NF-κB activation
  • Biological description

    Potent inhibitor of NF-κB activation. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in T cells.
  • Purity

    > 98%
  • CAS Number

    84573-16-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
  • Molecular weight

    505.56
  • Molecular formula

    C29H31NO7
  • PubChem identifier

    331783
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)C(=O)C1C(C2(C(C1O)(C3=C(C=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)OC)C5=CC= CC=C5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhu JY  et al. The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities. Int J Cancer 121:1839-46 (2007). Read more (PubMed: 17565740) »
  • Proksch P  et al. Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. J Immunol 174:7075-84 (2005). Read more (PubMed: 15905551) »
  • Baumann B  et al. Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. J Biol Chem 277:44791-800 (2002). Read more (PubMed: 12237314) »

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