Anti-ROCK2 (phospho Y722) antibody (ab182648)

Rabbit polyclonal ROCK2 (phospho Y722) antibody. Validated in WB and tested in Mouse, Rat, Human. Cited in 3 publication(s). Immunogen corresponding to synthetic peptide.

Overview

  • Product name

    Anti-ROCK2 (phospho Y722) antibody
    See all ROCK2 primary antibodies
  • Description

    Rabbit polyclonal to ROCK2 (phospho Y722)
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human ROCK2 (phospho Y722) conjugated to Keyhole Limpet Haemocyanin (KLH). Peptide sequence around phosphorylation site of Tyrosine 722 (K-I-Y(p)-E-S) derived from Human ROCK2.
    Database link: O75116

  • Positive control

    • Rat kidney extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab182648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 161 kDa.

Target

  • Function

    Regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction.
  • Sequence similarities

    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 protein kinase domain.
    Contains 1 REM (Hr1) repeat.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm. Cell membrane. Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • coiled-coil-containing protein kinase 2 antibody
    • KIAA0619 antibody
    • p164 ROCK 2 antibody
    • p164 ROCK-2 antibody
    • Rho associated coiled coil containing protein kinase 2 antibody
    • Rho associated protein kinase 2 antibody
    • Rho associated, coiled coil containing protein kinase II antibody
    • Rho kinase 2 antibody
    • Rho-associated antibody
    • Rho-associated protein kinase 2 antibody
    • ROCK 2 antibody
    • Rock II antibody
    • Rock2 antibody
    • ROCK2_HUMAN antibody
    • Rock2m antibody
    • ROK alpha antibody
    • ROKalpha antibody
    see all

Images

  • All lanes : Anti-ROCK2 (phospho Y722) antibody (ab182648) at 1/500 dilution

    Lane 1 : Rat kidney extract with antigen-specific peptide
    Lane 2 : Rat kidney extract

    Predicted band size: 161 kDa

References

This product has been referenced in:

  • Zhang X  et al. Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2. Cell Death Dis 9:190 (2018). Read more (PubMed: 29416017) »
  • Chen J  et al. A role for ErbB signaling in the induction of reactive astrogliosis. Cell Discov 3:17044 (2017). Read more (PubMed: 29238610) »
See all 3 Publications for this product

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