Rocuronium bromide, acetycholine receptor antagonist (ab142995)

Overview

  • Product name

    Rocuronium bromide, acetycholine receptor antagonist
  • Description

    Potent, reversible acetycholine receptor antagonist
  • Biological description

    Potent, reversible acetycholine receptor antagonist (IC50 values are 22.5 and 33.5 nM at AChRγ and AChRε respectively). Neuromuscular nondepolarizing agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    119302-91-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-Hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,
    17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate bromide
  • Molecular weight

    609.68
  • Molecular formula

    C32H53BrN2O4
  • PubChem identifier

    441351
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM, in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [C@H]1([C@H](C[C@]2([C@](C1)([C@]3([C@@](CC2)([C@]4([C@](CC3)([C@@H]([C@H](C4)[N+]5(CCCC5)CC=C)OC(=O)C)C)[H])[H])[H])C)[H])O)N6(CCOCC6).[Br-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhou RY  et al. Differences in sensitivity to rocuronium among orbicularis oris muscles innervated by normal or damaged facial nerves and gastrocnemius muscle innervated by somatic nerve in rats: combined morphological and functional analyses. Laryngoscope 122:1831-7 (2012). Read more (PubMed: 22522983) »
  • Wang H  et al. Different magnitude of resistance to nondepolarizing muscle relaxants in the denervated mouse skeletal muscle. Acta Pharmacol Sin 31:399-404 (2010). Read more (PubMed: 20305678) »
  • Bowman WC Neuromuscular block. Br J Pharmacol 147 Suppl 1:S277-86 (2006). Read more (PubMed: 16402115) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142995.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up