Overview

  • Product name

    Rofecoxib, COX-2 inhibitor NSAID 
  • Description

    Selective COX-2 inhibitor. NSAID.
  • Biological description

    Selective COX-2 inhibitor. NSAID. Inhibits prostaglandin biosynthesis. Shows anti-inflammatory, analgesic, and antipyretic effects in vivo. Orally active. Blood-brain barrier permeable.
  • CAS Number

    162011-90-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(4-Methylsulfonylphenyl)-4-phenyl-2H-furan-5-one
  • Molecular weight

    314.36
  • Molecular formula

    C17H14O4S
  • PubChem identifier

    5090
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gruen M  et al. Use of dynamic weight bearing as a novel end-point for the assessment of abdominal pain in the LPS-induced peritonitis model in the rat. J Neurosci Methods 232:118-24 (2014). Read more (PubMed: 24861422) »
  • Li X  et al. Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). FASEB J 27:4987-97 (2013). Read more (PubMed: 24005906) »
  • Miyajima A  et al. Disruption of elastic lamellae in aorta and dysfunction of vaso-regulation by rofecoxib in rats. J Toxicol Sci 38:719-29 (2013). Read more (PubMed: 24025789) »

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