Overview

  • Product name

    Romidepsin (FK228), HDAC1 and HDAC2 inhibitor
  • Description

    Potent HDAC1 and HDAC2 inhibitor
  • Alternative names

    • FK228
  • Biological description

    Potent HDAC1 and HDAC2 inhibitor (IC50 values are 36 and 47 nM at HDAC1 and HDAC2 respectively). Induces apoptosis, cell-cycle arrest and modulates cytokine expression in cancer cells. Antitumor agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    128517-07-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tiffon C  et al. The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells. Br J Pharmacol 162:1590-602 (2011). Read more (PubMed: 21198545) »
  • Furumai R  et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res 62:4916-21 (2002). Read more (PubMed: 12208741) »
  • Sasakawa Y  et al. Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo. Biochem Pharmacol 64:1079-90 (2002). Read more (PubMed: 12234611) »

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