Overview

  • Product name
  • Description
    Rabbit polyclonal to ROMO1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence corresponding to C terminal amino acids 49-79 (GRELMGGIGK TMMQSGGTFG TFMAIGMGIR C) of Human ROMO1.

  • Positive control
    • Human duodenum tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab121379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence.
  • Tissue specificity
    Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line.
  • Sequence similarities
    Belongs to the MGR2 family.
  • Developmental stage
    Expression increases in senescent cells.
  • Cellular localization
    Mitochondrion membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA353C18.2 antibody
    • C20orf52 antibody
    • Mitochondrial targeting GXXXG protein antibody
    • MTGMP antibody
    • Protein MGR2 homolog antibody
    • Reactive oxygen species modulator 1 antibody
    • ROMO1 antibody
    • ROMO1_HUMAN antibody
    • ROS modulator 1 antibody
    see all

Images

  • Immunofluorescent staining of Human cell line U-251MG shows positivity in nuclei but not nucleoli. Recommended concentration of ab121379 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121379 at 1/250 dilution staining ROMO1 in paraffin-embedded Human duodenum by Immunohistochemistry.

References

ab121379 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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