Overview

  • Product name

    Rosiglitazone potassium salt, PPARgamma agonist
  • Description

    Potent, selective PPARγ agonist. Water soluble.
  • Biological description

    Potent, selective PPARγ agonist (Kd = 43 nM, PPARγ ligand binding domain). Activates PPARγ expression (EC50 = 1 μM). Shows antidiabetic and hypoglycemic effects in vivo. Orally active. Water soluble.
  • Purity

    > 99%
  • CAS Number

    316371-84-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione potassium salt
  • Molecular weight

    395.52
  • Molecular formula

    C18H18KN3O3S
  • PubChem identifier

    11463585
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(CCOC1=CC=C(C=C1)CC2C(=O)[N-]C(=O)S2)C3=CC=CC=N3.[K+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bajwa PJ  et al. Activation of PPARgamma by rosiglitazone attenuates intestinal Cl- secretion. Am J Physiol Gastrointest Liver Physiol 297:G82-9 (2009). Read more (PubMed: 19443733) »
  • da Silva CA  et al. Rosiglitazone prevents sirolimus-induced hypomagnesemia, hypokalemia, and downregulation of NKCC2 protein expression. Am J Physiol Renal Physiol 297:F916-22 (2009). Read more (PubMed: 19656910) »
  • Riazi S  et al. Rosiglitazone regulates ENaC and Na-K-2Cl cotransporter (NKCC2) abundance in the obese Zucker rat. Am J Nephrol 26:245-57 (2006). Read more (PubMed: 16757903) »

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