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    rosiglitazone-ppargamma-agonist-ab120762.pdf

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Biochemicals Chemical Type Biochemicals
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Rosiglitazone, PPARgamma agonist (ab120762)

  • Datasheet
  • SDS
  • COA
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Functional Studies - Rosiglitazone, PPARgamma agonist (ab120762)

    Key features and details

    • Selective PPARγ agonist
    • CAS Number: 122320-73-4
    • Purity: > 99%
    • Soluble in DMSO to 100 mM and in ethanol to 100 mM (with warming)
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Rosiglitazone, PPARgamma agonist
    • Description

      Selective PPARγ agonist
    • Biological description

      Selective PPARγ agonist (EC50 = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.

    • Purity

      > 99%
    • CAS Number

      122320-73-4
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
    • Molecular weight

      357.43
    • Molecular formula

      C18H19N3O3S
    • PubChem identifier

      77999
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 100 mM (with warming)
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
    • Source

      Synthetic

    • Research areas

      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Nuclear Receptors
      • PPAR
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Biochemicals
      • Research Area
      • Cancer
      • Nuclear Receptors
      • PPAR
      • Biochemicals
      • Research Area
      • Heart disease
      • Nuclear Receptors
      • PPAR
      • Biochemicals
      • Research Area
      • Hypertension
      • Nuclear Receptors
      • PPAR
      • Biochemicals
      • Research Area
      • Stroke
      • Nuclear Receptors
      • PPAR

    Associated products

    • Related Products

      • PPAR gamma Transcription Factor Assay Kit (ab133101)
      • PPAR delta Transcription Factor Assay Kit (ab133106)
      • PPAR alpha Transcription Factor Assay Kit (ab133107)
      • PPAR (alpha, delta, gamma) Transcription Factor Assay Kit (ab133113)

    Applications

    Our Abpromise guarantee covers the use of ab120762 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    Images

    • Functional Studies - Rosiglitazone, PPARgamma agonist (ab120762)
      Functional Studies - Rosiglitazone, PPARgamma agonist (ab120762)
      ab3580 staining glucocorticoid receptor in serum starved HeLa cells treated with rosiglitazone (120762), by ICC/IF. Changes in localization of glucocorticoid receptor (translocation from cytoplasm to nucleous) correlates with increased concentration of rosiglitazone, as described in literature.
      The cells were incubated at 37°C for 1h in media containing different concentrations of ab120762 (rosiglitazone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab3580 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
    • COA
  • References (5)

    Publishing research using ab120762? Please let us know so that we can cite the reference in this datasheet.

    ab120762 has been referenced in 5 publications.

    • Katoh-Fukui Y  et al. Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones. Bone 120:219-231 (2019). PubMed: 30389610
    • Wu YX  et al. Iguratimod prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator-activated receptor-?. Mol Med Rep 16:8200-8208 (2017). PubMed: 28983607
    • Chen X  et al. Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs. BMC Musculoskelet Disord 18:423 (2017). PubMed: 29073887
    • Pinkosky SL  et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun 7:13457 (2016). PubMed: 27892461
    • Asimakopoulou A  et al. Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. Biochim Biophys Acta 1842:1513-24 (2014). PubMed: 25086218

    Customer reviews and Q&As

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