FITC Anti-Rotavirus antibody (ab31435)
Key features and details
- FITC Goat polyclonal to Rotavirus
- Suitable for: ICC/IF
- Reacts with: Rotavirus
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
Overview
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Product name
FITC Anti-Rotavirus antibody
See all Rotavirus primary antibodies -
Description
FITC Goat polyclonal to Rotavirus -
Host species
Goat -
Conjugation
FITC. Ex: 493nm, Em: 528nm -
Tested applications
Suitable for: ICC/IFmore details -
Species reactivity
Reacts with: Rotavirus -
Immunogen
Tissue, cells or virus corresponding to Rotavirus.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.20
Preservative: 0.1% Sodium azide
Constituents: 1% BSA, PBS -
Concentration information loading...
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Purity
Ion Exchange Chromatography -
Purification notes
Ammonium sulfate fractionation and ion-exchange chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab31435 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC/IF |
1/250. Acetone fixed.
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Notes |
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ICC/IF
1/250. Acetone fixed. |
Target
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Relevance
Rotaviruses, members of the family Reoviridae, are a major cause of diarrhoea in young mammals. Rotavirus infections also result in economic losses in agriculture due to diarrhoea in calf, pig, sheep, and poultry rearing. Diarrhoea (or scours) due to the rotavirus Nebraska Calf Diarrhea Virus can affect calves up to 30 days of age or older. Diarrhoea begins 2 to 3 days after exposure. Diagnosis is by history, lesions (ulcers on the tongue, lips, and mouth) and diagnostic laboratory tests. Mortality rates may be as high as 50 percent, depending on the secondary bacteria present. Human rotaviruses, the major aetiological agents of severe infantile diarrhoea worldwide, display surprisingly diverse and complex serotypic specificities. Rotaviruses are 70 nm, non enveloped viruses comprised of a triple layered protein capsid; Outer capsid proteins are VP4 and VP7, Inner capsid -VP6 and Core -VP2. The immunity acquired from exposure to rotavirus appears to be type specific following initial infection; therefore, multiple serotypes of rotavirus mean multiple opportunities for infection. The combination of animal reservoirs for the virus and rotavirus gene reassortment provides the potential for dramatic genetic shifts (similar to influenza virus) which could give rise to altered host ranges and viral virulence. -
Alternative names
- Major inner capsid protein VP6 antibody
- NSP4 antibody
- VP6 antibody
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab31435 has been referenced in 3 publications.
- Gozalbo-Rovira R et al. Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children. Int J Mol Sci 22:N/A (2021). PubMed: 33498321
- Ryabchevskaya EM et al. A Recombinant Rotavirus Antigen Based on the Coat Protein of Alternanthera Mosaic Virus. Mol Biol 54:243-248 (2020). PubMed: 32431461
- Buccigrossi V et al. Mechanisms of antidiarrhoeal effects by diosmectite in human intestinal cells. Gut Pathog 9:23 (2017). PubMed: 28450899