Rotenone, mitochondrial electron transport chain inhibitor (ab143145)

Overview

  • Product name

    Rotenone, mitochondrial electron transport chain inhibitor
  • Description

    Mitochondrial electron transport chain complex I inhibitor. Potent NADH oxidation inhibitor.
  • Purity

    > 97%
  • CAS Number

    83-79-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
  • Molecular weight

    394.42
  • Molecular formula

    C23H22O6
  • PubChem identifier

    6758
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 5 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC
  • Source

    Synthetic

References

This product has been referenced in:

  • Sanders LH  et al. Mitochondrial DNA Damage as a Peripheral Biomarker for Mitochondrial Toxin Exposure in Rats. Toxicol Sci : (2014). Read more (PubMed: 25237061) »
  • Bassani TB  et al. Neuroprotective and antidepressant-like effects of melatonin in a rotenone-induced Parkinson's disease model in rats. Brain Res : (2014). Read more (PubMed: 25301688) »
  • Gong LL  et al. Protective Effects of Akebia Saponin D Against Rotenone-Induced Hepatic Mitochondria Dysfunction. J Pharmacol Sci : (2014). Read more (PubMed: 25319614) »

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