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  1. Link

    rottlerin-kinase-inhibitor-ab120377.pdf

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Cell Biology Cell Cycle Kinases/Phosphatases Aurora
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Rottlerin, Kinase inhibitor (ab120377)

  • Datasheet
  • SDS
  • COA
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Key features and details

  • Kinase inhibitor
  • CAS Number: 82-08-6
  • Purity: > 95%
  • Soluble in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Rottlerin, Kinase inhibitor
  • Description

    Kinase inhibitor
  • Biological description

    Originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Also inhibits MAPKAP-K2 and PRAK (IC50 values are 5.4 and 1.9 μM, respectively), CHK2, PLK1, PIM3 and SRPK1.

  • Purity

    > 95%
  • CAS Number

    82-08-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
  • Molecular weight

    516.55
  • Molecular formula

    C30H28O8
  • PubChem identifier

    5281847
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)c4c(O)c(Cc2c(O)c(c1OC(C)(C)C=Cc1c2O)C(=O)/C=C/c3ccccc3)c(O)c(C)c4O
  • Source

    Synthetic

  • Research areas

    • Cell Biology
    • Cell Cycle
    • Kinases/Phosphatases
    • Aurora
    • Cell Biology
    • Cell Cycle
    • Kinases/Phosphatases
    • Other
    • Cell Biology
    • Cell Cycle
    • Cell Division
    • Spindle
    • Cell Biology
    • Apoptosis
    • Intracellular
    • Kinases
    • Cardiovascular
    • Blood
    • Other
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Phosphorylation
    • Epigenetics and Nuclear Signaling
    • Histones
    • H3
    • Phosphorylated
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Microfilaments
    • Actin etc
    • Actin
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Motor Proteins
    • Myosin
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Damage & Repair
    • DNA Damage Response
    • Chk1 / Chk2
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Damage & Repair
    • DNA Damage Response
    • ATM / ATR
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • PKC
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • MAPK Pathway
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • Aurora
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • Other Kinases
    • Signal Transduction
    • Signaling Pathway
    • Calcium Signaling
    • Calmodulin Pathway
    • Epigenetics and Nuclear Signaling
    • Histones
    • H2B
    • Phosphorylated
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • RNA Processing
    • Splicing
    • Neuroscience
    • Neurology process
    • Neuroendocrinology
    • Prolactin
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Cancer susceptibility
    • Proto-oncogenes
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Kinases/Phosphatases
    • Other
    • Cancer
    • Cell cycle
    • Cell division
    • Cancer
    • Cell cycle
    • Kinases/phosphatases
    • Aurora
    • Cancer
    • Cell cycle
    • Kinases/phosphatases
    • Other
    • Cancer
    • Signal transduction
    • Protein phosphorylation
    • Serine/threonine kinases
    • MAPK pathway
    • Cancer
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    • Protein phosphorylation
    • Serine/threonine kinases
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    • Biochemicals
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    • Biochemicals
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    • Pharmacology
    • Enzymes
    • Kinase
    • General
    • Inhibitors
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Kinase
    • Protein Kinase C
    • Inhibitors

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
    • COA
  • References (1)

    Publishing research using ab120377? Please let us know so that we can cite the reference in this datasheet.

    ab120377 has been referenced in 1 publication.

    • Hegazy AM  et al. Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance. J Biol Chem 291:21496-21509 (2016). PubMed: 27519418

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