Rottlerin, Kinase inhibitor (ab120377)
- Datasheet
- References (1)
Overview
-
Product name
Rottlerin, Kinase inhibitor -
Description
Kinase inhibitor -
Biological description
Originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Also inhibits MAPKAP-K2 and PRAK (IC50 values are 5.4 and 1.9 μM, respectively), CHK2, PLK1, PIM3 and SRPK1. -
Purity
> 95% -
CAS Number
82-08-6 -
Chemical structure
Properties
-
Chemical name
3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone -
Molecular weight
516.55 -
Molecular formula
C30H28O8 -
PubChem identifier
5281847 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(=O)c4c(O)c(Cc2c(O)c(c1OC(C)(C)C=Cc1c2O)C(=O)/C=C/c3ccccc3)c(O)c(C)c4O -
Source
Synthetic
-
Research areas
References
This product has been referenced in:
- Bain J et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007). Read more (PubMed: 17850214) »
- Davies SP et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105 (2000). Read more (PubMed: 10998351) »
- Gschwendt M et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199:93-8 (1994). Read more (PubMed: 8123051) »
