Roxatidine acetate hydrochloride, H2 receptor antagonist (ab143693)

Overview

  • Product name

    Roxatidine acetate hydrochloride, H2 receptor antagonist
  • Description

    Selective, competitive H2 receptor antagonist
  • Biological description

    Selective, competitive H2 receptor antagonist (IC50 = 3.2μM). Inhibits platelet function. Reduces VEGF expression. Inhibits gastric acid secretion and shows antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    93793-83-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [2-Oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate hydrochloride
  • Molecular weight

    384.90
  • Molecular formula

    C19H28N2O4.HCl
  • PubChem identifier

    56704
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM, in ethanol to 75 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Shikama N  et al. Different effects of two types of H2-receptor antagonists, famotidine and roxatidine, on the mucus barrier of rat gastric mucosa. Biomed Res 33:45-51 (2012). Read more (PubMed: 22361886) »
  • Cho EJ  et al. Roxatidine suppresses inflammatory responses via inhibition of NF-?B and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. J Cell Biochem 112:3648-59 (2011). Read more (PubMed: 21809375) »
  • Nagai N  et al. Drug interactions between theophylline and H2-antagonists, roxatidine acetate hydrochloride and cimetidine: pharmacokinetic analysis in rats in vivo. Biol Pharm Bull 18:1610-3 (1995). Read more (PubMed: 8593491) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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