Product nameRoyal jelly acid (10-Hydroxy-2-decenoic acid), VEGF inhibitor
Biological descriptionVEGF inhibitor. Inhibits VEGF-induced angiogenesis. Suppresses VEGF-induced endothelial cell proliferation and migration. Promotes neurogenesis. Shows antiangiogenic, antioxidant and DNA-protective effects in vivo. Orally active.
Chemical name(E)-10-Hydroxydec-2-enoic acid
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Amirshahi T et al. Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-?induced male rats. Iran J Reprod Med 12:209-16 (2014). Read more (PubMed: 24799882) »
- Izuta H et al. 10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. Evid Based Complement Alternat Med 6:489-94 (2009). Read more (PubMed: 18955252) »
- Hattori N et al. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed Res 28:261-6 (2007). Read more (PubMed: 18000339) »