Overview

  • Product name

    Rp-8-Br-cGMPS, cGMP blocker
  • Description

    cGMP blocker
  • Biological description

    cGMP blocker. Competitively inhibits relaxation elicited by 8-Br-cGMP in isolated rabbit aorta contracted by phenylephrine at 30 μM.
  • Purity

    > 98%
  • CAS Number

    150418-07-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Sodium Rp-8-bromoguanosine-3',5'-cyclic monophosphorothioate
  • Molecular weight

    462.20
  • Molecular formula

    C10H10BrNaN5O6PS
  • PubChem identifier

    44755026
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=S)(O1)[O-].[Na+]
  • Source

    Synthetic

References

This product has been referenced in:

  • Muller B  et al. Nitric oxide-related cyclic GMP-independent relaxing effect of N-acetylcysteine in lipopolysaccharide-treated rat aorta. Br J Pharmacol 123:1221-9 (1998). Read more (PubMed: 9559908) »
  • Armstead WM cGMP and cAMP in prostaglandin-induced pial artery dilation and increased CSF opioid concentration. Am J Physiol 271:H166-72 (1996). Read more (PubMed: 8760172) »
  • Nakazawa M & Imai S Rp-8-Br-guanosine-3',5'-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta. Eur J Pharmacol 253:179-81 (1994). Read more (PubMed: 8013545) »

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