Overview

  • Product name

    Anti-RPB7 antibody
  • Description

    Goat polyclonal to RPB7
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Cow, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to Human RPB7 aa 118-129 (internal sequence).
    Sequence:

    EFDPNSNPPCYK


    Database link: NP_002687.1

  • Positive control

    • Human brain cerebellum lysate
  • General notes

    Previously labelled as POLR2G. 

Properties

Applications

Our Abpromise guarantee covers the use of ab93352 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 21 kDa (predicted molecular weight: 19 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.
    • Sequence similarities

      Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
    • Cellular localization

      Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • DNA directed RNA polymerase II 19 kDa polypeptide antibody
      • DNA directed RNA polymerase II subunit G antibody
      • DNA directed RNA polymerase II subunit RPB7 antibody
      • DNA-directed RNA polymerase II subunit G antibody
      • DNA-directed RNA polymerase II subunit RPB7 antibody
      • hRPB19 antibody
      • hsRPB7 antibody
      • MGC138367 antibody
      • MGC138369 antibody
      • POLR2G antibody
      • polymerase (RNA) II (DNA directed) polypeptide G antibody
      • RNA polymerase II 19 kDa subunit antibody
      • RNA polymerase II subunit B7 antibody
      • RPB19 antibody
      • RPB7 antibody
      • RPB7_HUMAN antibody
      see all

    Images

    References

    ab93352 has not yet been referenced specifically in any publications.

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