Overview

  • Product name

  • Description

    Rabbit polyclonal to RPS19
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Pig, Orangutan
  • Immunogen

    Recombinant full length protein corresponding to Human RPS19 aa 1-145.
    Sequence:

    MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDE NWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVA RRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH


    Database link: P39019

  • Positive control

    • HL-60, PC-3, MCF-7, A549, 293T, HepG2 and SW620 cell extracts.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab187197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 16 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
  • Tissue specificity

    Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.
  • Involvement in disease

    Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1) [MIM:105650]. DBA1 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
  • Sequence similarities

    Belongs to the ribosomal protein S19e family.
  • Cellular localization

    Nucleus. Located more specifically in the nucleoli.
  • Information by UniProt
  • Database links

  • Alternative names

    • 40S ribosomal protein S19 antibody
    • DBA antibody
    • DBA1 antibody
    • HGNC:10402 antibody
    • Ribosomal protein S19 antibody
    • rps19 antibody
    • RS19_HUMAN antibody
    • S19 antibody
    see all

Images

  • All lanes : Anti-RPS19 antibody (ab187197) at 1/500 dilution

    Lane 1 : HL-60 cell extract
    Lane 2 : PC-3 cell extract
    Lane 3 : MCF-7 cell extract
    Lane 4 : A549 cell extract
    Lane 5 : 293T cell extract
    Lane 6 : Hep-G2 cell extract
    Lane 7 : SW620 cell extract

    Predicted band size: 16 kDa

References

ab187197 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab187197.
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