Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction.
Belongs to the RRN3 family.
Phosphorylation is required for participation in rDNA transcription.
ab112052 at 1 µg/ml staining RRN3 in HeLa whole cell lysate immunoprecipitated using ab112052 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Lane 2: controle IgG.
Predicted band size : 74 kDa
Exposure time: 10 seconds
Wei T et al. Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint. Cell Rep23:404-414 (2018).
Read more (PubMed: 29642000) »
Tanaka Y et al.
Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation.
Mol Cell Biol35:4170-84 (2015).
Read more (PubMed: 26416883) »