For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Customized Products & Partnerships
    Customized Products & Partnerships

    Customized products and commercial partnerships to accelerate your diagnostic and therapeutic programs.

    Customized products

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

  1. Link

    rs-35-dhpg-group-i-mglu-receptor-agonist-ab120020.pdf

  1. Send me a copy of this email
    I agree to the terms and conditions.
Neuroscience Neurotransmitter Amino Acids Glutamate
Share by email

(R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (4)

Product price, shipping and contact information

Currently unavailable

Sorry, we can't display this right now.

Please contact us to place your order, or try again later.

 

Loading size & price…

 

Shipping and order information

Shipping info

Promotion Information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Chemical Structure - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)
  • Functional Studies - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)

Key features and details

  • Group I mGlu receptor agonist
  • CAS Number: 19641-83-9
  • Soluble in water to 10 mM
  • Form / State: Solid
  • Source: Synthetic

You may also be interested in

Conjugation
Product image
APC/Cy5.5® Conjugation Kit - Lightning-Link® (ab102855)
Biochemical
Product image
QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (ab120117)
Primary
Product image
Anti-C2 antibody [EPR17979] (ab209900)

View more associated products

Overview

  • Product name

    (R,S)-3,5-DHPG, group I mGlu receptor agonist
  • Description

    Group I mGlu receptor agonist
  • Biological description

    Selective group I mGlu receptor agonist

    Also available in simple stock solutions (ab146669) - add 1 ml of water to get an exact, ready-to-use concentration.

  • CAS Number

    19641-83-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (R,S)-3,5-Dihydroxyphenylglycine
  • Molecular weight

    183.16
  • Molecular formula

    C8H9NO4
  • PubChem identifier

    108001
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in water to 10 mM
  • Handling

    This compound is also unstable in alkaline solution when it rapidly forms a brown colouration it is therefore recommended that alkaline is not used to dissolve this compound.

    We recommend stock solutions are made up in water, aliquoted immediately and stored at -20°C. They should be used within one week.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc1cc(cc(O)c1)C(N)C(=O)O
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Amino Acids
    • Glutamate
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Glutamate Receptors
    • Signal Transduction
    • Signaling Pathway
    • G Protein Signaling
    • GPCR
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Amino Acid
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Glutamate
    • mGlu
    • Group I
    • Agonists
    • Biochemicals
    • Research Area
    • Addiction
    • Glutamate
    • mGlu
    • Group I
    • Agonists
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Glutamate
    • mGlu
    • Group I
    • Agonists
    • Biochemicals
    • Research Area
    • Depression
    • Glutamate
    • mGlu
    • Group I
    • Agonists
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Glutamate
    • mGlu
    • Group I
    • Agonists
    • Biochemicals
    • Research Area
    • Parkinson's Disease
    • Glutamate
    • mGlu
    • Group I
    • Agonists
    • Biochemicals
    • Research Area
    • Schizophrenia
    • Glutamate
    • mGlu
    • Group I
    • Agonists
    • Biochemicals
    • Research Area
    • Stroke
    • Glutamate
    • mGlu
    • Group I
    • Agonists

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab120020 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)
    Chemical Structure - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)
    2D chemical structure image of ab120020, (R,S)-3,5-DHPG, group I mGlu receptor agonist
  • Functional Studies - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)
    Functional Studies - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)
    ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-3,5-DHPG (ab120020), by ICC/IF. Increase in FMRP expression correlates with increased concentration of (R,S)-3,5-DHPG, as described in literature.
    The cells were incubated at 37°C for 1h in media containing different concentrations of ab120020 ((R,S)-3,5-DHPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (4)

Publishing research using ab120020? Please let us know so that we can cite the reference in this datasheet.

ab120020 has been referenced in 4 publications.

  • Bowling H  et al. Altered steady state and activity-dependent de novo protein expression in fragile X syndrome. Nat Commun 10:1710 (2019). PubMed: 30979884
  • Li JQ  et al. Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J Neurochem 112:162-72 (2010). PubMed: 19840219
  • Roloff AM  et al. Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity. J Neurosci 30:3072-81 (2010). PubMed: 20181604
  • Musante V  et al. Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings. Neuropharmacology 55:474-82 (2008). PubMed: 18625255

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

There are currently no Customer reviews or Questions for ab120020.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Get resources and offers direct to your inbox Sign up
A-Z by research area
  • Cancer
  • Cardiovascular
  • Cell biology
  • Developmental biology
  • Epigenetics & Nuclear signaling
  • Immunology
  • Metabolism
  • Microbiology
  • Neuroscience
  • Signal transduction
  • Stem cells
A-Z by product type
  • Primary antibodies
  • Secondary antibodies
  • Biochemicals
  • Isotype controls
  • Flow cytometry multi-color selector
  • Kits
  • Loading controls
  • Lysates
  • Peptides
  • Proteins
  • Slides
  • Tags and cell markers
  • Tools & Reagents
Help & support
  • Support
  • Make an Inquiry
  • Protocols & troubleshooting
  • Placing an order
  • RabMAb products
  • Biochemical product FAQs
  • Training
  • Browse by Target
Company
  • Corporate site
  • Investor relations
  • Company news
  • Careers
  • About us
  • Blog
Events
  • Tradeshows
  • Conferences
International websites
  • abcam.cn
  • abcam.co.jp

Join with us

  • LinkedIn
  • facebook
  • Twitter
  • YouTube
  • Terms of sale
  • Website terms of use
  • Cookie policy
  • Privacy policy
  • Legal
  • Modern slavery statement
© 1998-2022 Abcam plc. All rights reserved.