(R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)
- Datasheet
- References (4)
Overview
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Product name
(R,S)-3,5-DHPG, group I mGlu receptor agonist -
Description
Group I mGlu receptor agonist -
Biological description
Selective group I mGlu receptor agonist
Also available in simple stock solutions (ab146669) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 98% -
CAS Number
19641-83-9 -
Chemical structure
Properties
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Chemical name
(R,S)-3,5-Dihydroxyphenylglycine -
Molecular weight
183.16 -
Molecular formula
C8H9NO4 -
PubChem identifier
108001 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in water to 10 mM -
Handling
This compound is also unstable in alkaline solution when it rapidly forms a brown colouration it is therefore recommended that alkaline is not used to dissolve this compound.
We recommend stock solutions are made up in water, aliquoted immediately and stored at -20°C. They should be used within one week.Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc1cc(cc(O)c1)C(N)C(=O)O -
Source
Synthetic
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Research areas
Associated products
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Related Products
Applications
Our Abpromise guarantee covers the use of ab120020 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Functional Studies | Use at an assay dependent concentration. |
Images
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Functional Studies - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-3,5-DHPG (ab120020), by ICC/IF. Increase in FMRP expression correlates with increased concentration of (R,S)-3,5-DHPG, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120020 ((R,S)-3,5-DHPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
References
This product has been referenced in:
- Lin FF et al. Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype. Neuropharmacology 36:917-31 (1997). Read more (PubMed: 9257936) »
- Brabet I et al. Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses. Neuropharmacology 34:895-903 (1995). Read more (PubMed: 8532171) »
- Ito I et al. 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. Neuroreport 3:1013-6 (1992). Read more (PubMed: 1362358) »
