(R,S)-Anabasine, Nicotinic receptor agonist (ab144918)

Overview

  • Product name

    (R,S)-Anabasine, Nicotinic receptor agonist
  • Description

    Nicotinic receptor agonist.
  • Alternative names

    • (+/-)-Anabasine
    • (R,S)-3-(2-Piperidinyl)pyridine
    • 1,2,3,4,5,6-Hexahydro-[2,3’]bipyridinyl; 2-(3-Pyridyl)piperidine
    • 2-(3-Pyridyl)piperidine
    • 3-(Piperidin-2-yl)pyridine
    • Anabasine
    • DL-Anabasine
    • Neonicotine
    see all
  • Biological description

    Nicotinic receptor agonist. Used as a biomarker of active tobacco use. Inhibits androstenedione conversion to estrogen in a dose-dependent manner.


     

  • CAS Number

    13078-04-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(2-Piperidinyl)pyridine
  • Molecular weight

    162.23
  • Molecular formula

    C10H14N2
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • von Weymarn LB  et al. Quantitation of the Minor Tobacco Alkaloids Nornicotine, Anatabine, and Anabasine in Smokers' Urine by High Throughput Liquid Chromatography-Mass Spectrometry. Chem Res Toxicol 29:390-7 (2016). Read more (PubMed: 26825008) »
  • Ciesla L  et al. Development and characterization of the a3ß4a5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts. J Chromatogr A 1431:138-44 (2016). Read more (PubMed: 26774122) »
  • Barbieri RL  et al. Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. J Clin Invest 77:1727-33 (1986). Read more (PubMed: 3711333) »

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