Overview

  • Product name

    (R,S)-Sulforaphane, antagonist of Ah receptor
  • Description

    Potent, non-competitive antagonist of Ah receptor
  • Biological description

    Potent, non-competitive antagonist of the aryl hydrocarbon (Ah) receptor (IC50 = 1 μM). Isothiocyanate. Induces epoxide hydrolase. Anticarcinogenic. Active in vivo and in vitro.
  • Purity

    > 99%
  • General notes

    This compound is a neat liquid at room temperature, clear to slightly yellow in color. It is not dissolved in solvent. In small quantities the material will coat the sides of the ampule it is shipped in and may appear to be invisible, or it may be trapped in the tip of the ampule. Wash the upper and lower parts of the ampule with solvent to ensure all of the material is obtained.

  • CAS Number

    4478-93-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Abdull Razis AF  et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol 86:1505-14 (2012). Read more (PubMed: 22643862) »
  • Abdull Razis AF  et al. Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Arch Toxicol 85:919-27 (2011). Read more (PubMed: 21132492) »
  • Zhang Y  et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci U S A 91:3147-50 (1994). Read more (PubMed: 8159717) »

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