Key features and details
- Mouse polyclonal to RS1
- Suitable for: WB
- Reacts with: Human, Zebrafish
- Isotype: IgG
Product nameAnti-RS1 antibody
See all RS1 primary antibodies
DescriptionMouse polyclonal to RS1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human, Zebrafish
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.4
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab167579 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa.|
FunctionMay be active in cell adhesion processes during retinal development.
Tissue specificityRestricted to the retina (at protein level). At the mRNA level, detected only within the photoreceptor cell layer, most prominently within the inner segments of the photoreceptors. Undetectable in the inner plexiform layers and the inner nuclear layer. At the protein level, found in the inner segment of the photoreceptors, the inner nuclear layer, the inner plexiform layer and the ganglion cell layer. At the macula, expressed in both the outer and inner nuclear layers and in the inner plexiform layer (at protein level).
Involvement in diseaseDefects in RS1 are the cause of retinoschisis juvenile X-linked type 1 (XLRS1) [MIM:312700]. A vitreo-retinal dystrophy characterized by macular pathology and by splitting of the superficial layer of the retina. Macular changes are present in almost all cases. In the fundi, radially oriented intraretinal foveomacular cysts are seen in a spoke-wheel configuration, with the absence of foveal reflex in most cases. In addition, approximately half of cases have bilateral peripheral retinoschisis in the inferotemporal part of the retina. Aside from the typical fundus appearance, strabismus, nystagmus, axial hyperopia, defective color vision and foveal ectopy can be present. The most important complications are vitreous hemorrhage, retinal detachment, and neovascular glaucoma.
Sequence similaritiesContains 1 F5/8 type C domain.
Developmental stageUp-regulated during the differentiation of a retinoblastoma cell line.
- Information by UniProt
- Retinoschisin antibody
- RS1 antibody
- X-linked juvenile retinoschisis protein antibody
- XLRS1_HUMAN antibody
ab167579 has been referenced in 1 publication.
- MacDonald RB et al. Müller glia provide essential tensile strength to the developing retina. J Cell Biol 210:1075-83 (2015). PubMed: 26416961