Overview

  • Product name

    Anti-RSK3 (phospho T356 + S360) antibody
    See all RSK3 primary antibodies
  • Description

    Rabbit polyclonal to RSK3 (phospho T356 + S360)
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide within Human RSK3 (internal sequence) (phospho T356 + S360). The exact sequence is proprietary. Conjugated to a carrier protein.
    Database link: Q15349

  • Positive control

    • WB: Serum starved A431 cells treated with EGF whole cell extracts. A431 whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab226952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 83 kDa.

Target

  • Function

    Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
  • Tissue specificity

    Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
  • Sequence similarities

    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 2 protein kinase domains.
  • Post-translational
    modifications

    Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1.
    N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Cellular localization

    Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • 90 kDa ribosomal protein S6 kinase 2 antibody
    • HU 2 antibody
    • KS6A2_HUMAN antibody
    • MAP kinase activated protein kinase 1c antibody
    • MAP kinase-activated protein kinase 1c antibody
    • MAPK-activated protein kinase 1c antibody
    • MAPKAP kinase 1c antibody
    • MAPKAPK-1c antibody
    • MAPKAPK1C antibody
    • Mitogen.activated protein kinase-activated protein kinase 1C antibody
    • p90 RSK3 antibody
    • p90-RSK 2 antibody
    • p90RSK2 antibody
    • pp90RSK3 antibody
    • Ribosomal protein S6 kinase alpha-2 antibody
    • ribosomal protein S6 kinase, 90kDa, polypeptide 2 antibody
    • Ribosomal S6 kinase 3 antibody
    • RPS6KA2 antibody
    • RSK 3 antibody
    • RSK antibody
    • RSK-3 antibody
    • S6K alpha antibody
    • S6K alpha 2 antibody
    • S6K-alpha-2 antibody
    see all

Images

  • All lanes : Anti-RSK3 (phospho T356 + S360) antibody (ab226952) at 1/1000 dilution

    Lane 1 : A431 (human epidermoid carcinoma cell line), starved for 24 hours, whole cell extract
    Lane 2 : A431 (human epidermoid carcinoma cell line), starved for 24 hours and treated with 200 ng/ml EGF for 15 minutes, whole cell extract

    Secondary
    All lanes : HRP-conjugated anti-rabbit IgG

    Predicted band size: 83 kDa

References

ab226952 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab226952.
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