Anti-RST antibody - C-terminal (ab198791)
Key features and details
- Rabbit polyclonal to RST - C-terminal
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-RST antibody - C-terminal
See all RST primary antibodies -
Description
Rabbit polyclonal to RST - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human RST aa 528-540 (C terminal).
Database link: Q96S37 -
Positive control
- HeLa and 293T cell lysates. Human liver cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198791 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/200 - 1/1000. Predicted molecular weight: 59 kDa.
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Notes |
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WB
1/200 - 1/1000. Predicted molecular weight: 59 kDa. |
Target
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Function
Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. -
Tissue specificity
Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex. -
Involvement in disease
Defects in SLC22A12 are a cause of renal hypouricemia (RH) [MIM:220150]. Patients have low serum urate levels, due to defects in renal urate re-absorption and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure (ARF), chronic renal dysfunction and uric acid urolithiasis. -
Sequence similarities
Belongs to the major facilitator superfamily. Organic cation transporter family. -
Cellular localization
Cell membrane. Detected in the luminal membrane of the epithelium of renal proximal tubules. - Information by UniProt
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Database links
- Entrez Gene: 116085 Human
- Omim: 607096 Human
- SwissProt: Q96S37 Human
- Unigene: 174424 Human
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Alternative names
- Organic anion transporter 4-like protein antibody
- Renal-specific transporter antibody
- RST antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab198791 has not yet been referenced specifically in any publications.