Overview

  • Product name

    Anti-RST antibody - C-terminal
    See all RST primary antibodies
  • Description

    Rabbit polyclonal to RST - C-terminal
  • Host species

    Rabbit
  • Specificity

    This antibody detects endogenous levels of total RST protein.
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human RST aa 528-540 (C terminal).
    Database link: Q96S37

  • Positive control

    • HeLa and 293T cell lysates. Human liver cancer tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab198791 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.
WB 1/200 - 1/1000. Predicted molecular weight: 59 kDa.

Target

  • Function

    Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.
  • Tissue specificity

    Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.
  • Involvement in disease

    Defects in SLC22A12 are a cause of renal hypouricemia (RH) [MIM:220150]. Patients have low serum urate levels, due to defects in renal urate re-absorption and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure (ARF), chronic renal dysfunction and uric acid urolithiasis.
  • Sequence similarities

    Belongs to the major facilitator superfamily. Organic cation transporter family.
  • Cellular localization

    Cell membrane. Detected in the luminal membrane of the epithelium of renal proximal tubules.
  • Information by UniProt
  • Database links

  • Alternative names

    • Organic anion transporter 4-like protein antibody
    • Renal-specific transporter antibody
    • RST antibody
    • S22AC_HUMAN antibody
    • Slc22a12 antibody
    • Solute carrier family 22 member 12 antibody
    • Urate anion exchanger 1 antibody
    see all

Images

  • All lanes : Anti-RST antibody - C-terminal (ab198791) at 1/200 dilution

    Lane 1 : Hela cell lysate
    Lane 2 : 293T cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 59 kDa


    Exposure time: 40 seconds


    8% SDS PAGE

References

ab198791 has not yet been referenced specifically in any publications.

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