Overview

  • Product name

    RU 24969 hemisuccinate, 5-HT1A/1B agonist
  • Description

    Potent 5-HT1A/1B agonist
  • Alternative names

    • 5-methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole
  • Biological description

    Potent 5-HT1A/1B agonist (ED50 = 236 nM). Locomotor-activating effects. Centrally active. Active in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    66611-27-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate
  • Molecular weight

    287.34
  • Molecular formula

    C14H16N2O.0.5C4H6O4
  • PubChem identifier

    3050530
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wesolowska A  et al. Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. Eur J Pharmacol 541:57-63 (2006). Read more (PubMed: 16765343) »
  • Iravani MM  et al. 3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. J Neurosci 23:9107-15 (2003). Read more (PubMed: 14534244) »
  • Martinez-Price DL & Geyer MA Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats. Pharmacol Biochem Behav 71:569-80 (2002). Read more (PubMed: 11888548) »
  • Jacoby HI  et al. Central and peripheral administration of serotonin produces opposite effects on mouse colonic propulsive motility. Neurosci Lett 122:122-6 (1991). Read more (PubMed: 2057128) »
  • Brazell MP  et al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol 86:209-16 (1985). Read more (PubMed: 2413936) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146299.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up