Key features and details
- Caged K+ channel blocker, uncaged by visible light
- CAS Number:
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Product nameRuBi-4AP, Caged K+ channel blocker
DescriptionCaged K+ channel blocker, uncaged by visible light
Water soluble caged 4-aminopyridine (4-AP) based on ruthenium photochemistry. Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases voltage-dependent K+ channel blocker 4-aminopyridine (ab120122) when uncaged.
RuBi-4AP is light sensitive and it is recommended that the compound is protected from light.Sold under license from Columbia University; Patent Pending
Chemical nameBis(2,2'-bipyridine-N,N')bis(4-aminopyridine-N1) ruthenium(2+) dichloride complex
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120410 has been referenced in 1 publication.
- Rowan MJ et al. Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. J Neurosci 34:6611-23 (2014). PubMed: 24806686