Key features and details
- Novel caged-GABA compound, uncaged by visible light
- CAS Number: 1028141-88-9
- Soluble in DMSO to 25 mM. For water solubility, please refer to Guideline for Use Information Sheet
- Form / State: Solid
- Source: Synthetic
Product nameRuBi-GABA, caged-GABA compound
DescriptionNovel caged-GABA compound, uncaged by visible light
Novel caged-GABA compound that uses a ruthenium complex as photosensor. Can be excited with visible wavelengths, providing greater tissue penetration, less photo-toxicity, and faster photorelease kinetics than other UV light-sensitive caged compounds. Can be used for GABA receptor mapping, and optical silencing of neuronal firing.
RuBi-GABA is light sensitive and it is recommended that the compound is protected from light.Sold under license from Columbia University; Patent Pending
Chemical name(Bis(2,2'-bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 25 mM. For water solubility, please refer to Guideline for Use Information Sheet
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
ab120409 has been referenced in 5 publications.
- Goutierre M et al. KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels. Cell Rep 28:91-103.e7 (2019). PubMed: 31269453
- Imbriglio T et al. Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors. FASEB J 33:14204-14220 (2019). PubMed: 31665922
- Lin WC et al. A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition. Neuron 88:879-891 (2015). PubMed: 26606997
- Zayat L et al. Ruthenium polypyridyl phototriggers: from beginnings to perspectives. Philos Trans A Math Phys Eng Sci 371:20120330 (2013). PubMed: 23776299
- Gauvain G et al. The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines. Proc Natl Acad Sci U S A 108:15474-9 (2011). PubMed: 21878564