Product nameRuBi-Glutamate, caged-glutamate compound
DescriptionNovel caged-glutamate compound, uncaged by visible light
Biological descriptionNovel caged-glutamate compound based on ruthenium photochemistry. Excited with visible wavelengths and releases glutamate after one- or two-photon excitation. It has high quantum efficiency and can be used at low concentrations. Enables the photoactivation of neuronal dendrites and circuits with visible or two-photon light sources, achieving single cell, or even single spine, precision.
Also available in simple stock solutions (ab146718) - add 1 ml of water to get an exact, ready-to-use concentration.
RuBi-Glutamate is light sensitive and it is recommended that the compound is protected from light.
Sold under license from Columbia University; Patent Pending.
Chemical name(Bis(2,2'-bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in water to 20 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Broad spectrum / non-selective
This product has been referenced in:
- Salierno M et al. A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes. J Inorg Biochem 104:418-22 (2010). Read more (PubMed: 20060592) »
- Fino E et al. RuBi-Glutamate: Two-Photon and Visible-Light Photoactivation of Neurons and Dendritic spines. Front Neural Circuits 3:2 (2009). Read more (PubMed: 19506708) »