Anti-RUNX1T1/ETO/CDR antibody (ab220347)
Key features and details
- Rabbit polyclonal to RUNX1T1/ETO/CDR
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-RUNX1T1/ETO/CDR antibody
See all RUNX1T1/ETO/CDR primary antibodies -
Description
Rabbit polyclonal to RUNX1T1/ETO/CDR -
Host species
Rabbit -
Tested applications
Suitable for: ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Human RUNX1T1/ETO/CDR aa 400-500.
Database link: Q06455 -
Positive control
- HEK 293 cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab220347 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
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Notes |
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ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
Target
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Function
Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12. -
Tissue specificity
Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. -
Involvement in disease
Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.
Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:114500]. -
Sequence similarities
Belongs to the CBFA2T family.
Contains 1 MYND-type zinc finger.
Contains 1 TAFH (NHR1) domain. -
Domain
The TAFH domain mediates interaction with transcription regulators. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 862 Human
- Entrez Gene: 12395 Mouse
- Entrez Gene: 362489 Rat
- Omim: 133435 Human
- SwissProt: Q06455 Human
- SwissProt: Q61909 Mouse
- Unigene: 368431 Human
- Unigene: 470961 Mouse
see all -
Alternative names
- Acute myelogenous leukemia 1 translocation 1 cyclin D related antibody
- Acute myelogenous leukemia 1 translocation 1 protein antibody
- AML1 MTG8 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab220347 has not yet been referenced specifically in any publications.