Ruxolitinib, ATP-competitive JAK1/2 inhibitor (ab141356)

Overview

  • Product name

    Ruxolitinib, ATP-competitive JAK1/2 inhibitor
  • Description

    Potent, selective ATP-competitive JAK1/2 inhibitor
  • Alternative names

    • (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
    • INCA24
    • INCB 018424
  • Biological description

    Potent, selective ATP-competitive Janus-associated kinase 1 and 2 inhibitor (IC50 values of 3.3, 2.8 and 428 nM for JAK1, JAK2 and JAK3 respectively in vitro). Inhibits IL-6 signaling (IC50 = 281nM). Orally bioavailable.

  • Purity

    > 99%
  • CAS Number

    941678-49-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

  • Molecular weight

    306.37
  • Molecular formula

    C17H18N6
  • PubChem identifier

    25126798
  • Storage instructions

    Shipped at room temperature. Store at -20°C.
  • Solubility overview

    Soluble in DMSO to 16 mM and in ethanol to 32 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
  • Source

    Synthetic

References

This product has been referenced in:

  • Quintás-Cardama A  et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 115:3109-17 (2010). Read more (PubMed: 20130243) »
  • Verstovsek S Therapeutic potential of JAK2 inhibitors. Hematology Am Soc Hematol Educ Program N/A:636-42 (2009). Read more (PubMed: 20008249) »

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