Overview

  • Product name

    Anti-Ryanodine receptor 2/RYR-2 antibody - N-terminal
    See all Ryanodine receptor 2/RYR-2 primary antibodies
  • Description

    Rabbit polyclonal to Ryanodine receptor 2/RYR-2 - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit
  • Immunogen

    Synthetic peptide within Human Ryanodine receptor 2/RYR-2 (N terminal). The exact sequence is proprietary.
    Database link: Q92736

  • General notes

    Previously labelled as Ryanodine receptor 2

Properties

Applications

Our Abpromise guarantee covers the use of ab196355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 565 kDa.

Target

  • Function

    Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
  • Tissue specificity

    Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
  • Involvement in disease

    Familial arrhythmogenic right ventricular dysplasia 2
    Ventricular tachycardia, catecholaminergic polymorphic 1, with or without atrial dysfunction and/or dilated cardiomyopathy
  • Sequence similarities

    Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.
    Contains 3 B30.2/SPRY domains.
    Contains 5 MIR domains.
  • Developmental stage

    Expressed in myometrium during pregnancy.
  • Domain

    The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.
  • Post-translational
    modifications

    Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels.
    Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.
  • Cellular localization

    Sarcoplasmic reticulum membrane. Membrane. The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.
  • Information by UniProt
  • Database links

  • Alternative names

    • ARVC2 antibody
    • ARVD2 antibody
    • Cardiac muscle ryanodine receptor antibody
    • Cardiac muscle ryanodine receptor-calcium release channel antibody
    • hRYR-2 antibody
    • ryanodine receptor 2 (cardiac) antibody
    • Ryanodine receptor 2 antibody
    • RyR antibody
    • RYR-2 antibody
    • RyR2 antibody
    • RYR2_HUMAN antibody
    • Type 2 ryanodine receptor antibody
    • VTSIP antibody
    see all

References

ab196355 has not yet been referenced specifically in any publications.

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