Anti-Ryanodine Receptor antibody [34C] (ab2868)

Mouse monoclonal Ryanodine Receptor antibody [34C]. Validated in WB, IP, IHC, Inhibition, ICC/IF and tested in Mouse, Rat, Sheep, Rabbit, Cow, Dog, Human, Pig, Xenopus laevis, Non human primates.

Publishing research using ab2868? Please let us know so that we can cite the reference in this datasheet.

ab2868 has been referenced in 38 publications.

  • Zügel M  et al. Moderate intensity continuous training reverses the detrimental effects of ovariectomy on RyR1 phosphorylation in rat skeletal muscle. Mol Cell Endocrinol 481:1-7 (2019). PubMed: 30465874
  • Estañ MC  et al. Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. Nat Commun 10:797 (2019). PubMed: 30770808
  • Aloni E  et al. Synaptopodin Deficiency Ameliorates Symptoms in the 3xTg Mouse Model of Alzheimer's Disease. J Neurosci 39:3983-3992 (2019). PubMed: 30872324
  • Jacko D  et al. Resistance exercise-induced muscle fatigue is not accompanied by increased phosphorylation of ryanodine receptor 1 at serine 2843. PLoS One 13:e0199307 (2018). PubMed: 29953482
  • El-Ajouz S  et al. Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A. J Physiol 595:4769-4784 (2017). IP . PubMed: 28387457
  • Bernadzki KM  et al. Liprin-a-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery. Sci Rep 7:9116 (2017). PubMed: 28831123
  • Correll RN  et al. Mitsugumin 29 regulates t-tubule architecture in the failing heart. Sci Rep 7:5328 (2017). ICC/IF ; Mouse . PubMed: 28706255
  • Llano-Diez M  et al. Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy. Crit Care 20:254 (2016). PubMed: 27510990
  • Pryadkina M  et al. A comparison of AAV strategies distinguishes overlapping vectors for efficient systemic delivery of the 6.2?kb Dysferlin coding sequence. Mol Ther Methods Clin Dev 2:15009 (2015). IHC . PubMed: 26029720
  • Place N  et al. Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise. Proc Natl Acad Sci U S A 112:15492-7 (2015). PubMed: 26575622
  • Olsson K  et al. Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes. Skelet Muscle 5:26 (2015). WB ; Human . PubMed: 26301072
  • Lugenbiel P  et al. Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. PLoS One 10:e0116395 (2015). WB . PubMed: 25775120
  • Fernandez-Sanz C  et al. Defective sarcoplasmic reticulum-mitochondria calcium exchange in aged mouse myocardium. Cell Death Dis 5:e1573 (2014). WB, ICC/IF ; Mouse . PubMed: 25522267
  • Yang W  et al. Calcium concentration response to uterine ischemia: a comparison of uterine fibroid cells and adjacent normal myometrial cells. Eur J Obstet Gynecol Reprod Biol 174:123-7 (2014). Human . PubMed: 24405728
  • Wright MF  et al. Mechanisms of intracellular calcium homeostasis in developing and mature bovine corpora lutea. Biol Reprod 90:55 (2014). WB, IHC-P ; Cow . PubMed: 24501170
  • Yamada T  et al. Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness. Ann Rheum Dis N/A:N/A (2014). WB ; Human . PubMed: 24854355
  • Vihola A  et al. Altered expression and splicing of Ca(2+) metabolism genes in myotonic dystrophies DM1 and DM2. Neuropathol Appl Neurobiol 39:390-405 (2013). WB ; Human . PubMed: 22758909
  • Wu B  et al. Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proc Natl Acad Sci U S A 110:15091-6 (2013). WB ; Mouse . PubMed: 23918386
  • Broucqsault N  et al. Dysregulation of 4q35- and muscle-specific genes in fetuses with a short D4Z4 array linked to facio-scapulo-humeral dystrophy. Hum Mol Genet 22:4206-14 (2013). WB . PubMed: 23777630
  • Abcejo AJ  et al. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PLoS One 7:e44343 (2012). WB . PubMed: 22952960
  • Blaich A  et al. Mutation of the Calmodulin Binding Motif IQ of the L-type Cav1.2 Ca2+ Channel to EQ Induces Dilated Cardiomyopathy and Death. J Biol Chem 287:22616-25 (2012). WB ; Mouse . PubMed: 22589547
  • Perálvarez-Marín A  et al. 3D Mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM. PLoS One 6:e25813 (2011). PubMed: 21998699
  • Lostal W  et al. Efficient recovery of dysferlin deficiency by dual adeno-associated vector-mediated gene transfer. Hum Mol Genet 19:1897-907 (2010). IHC-Fr ; Mouse . PubMed: 20154340
  • Pfeffer M  et al. The mammalian molecular clockwork controls rhythmic expression of its own input pathway components. J Neurosci 29:6114-23 (2009). IHC ; Mouse . PubMed: 19439589
  • Zhang Q  et al. R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nat Cell Biol 9:453-60 (2007). PubMed: 17369816
  • Zhou H  et al. Molecular mechanisms and phenotypic variation in RYR1-related congenital myopathies. Brain 130:2024-36 (2007). WB . PubMed: 17483490
  • Zhou H  et al. Characterization of recessive RYR1 mutations in core myopathies. Hum Mol Genet 15:2791-803 (2006). WB . PubMed: 16940308
  • Zhang Q  et al. Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. J Cell Sci 118:673-87 (2005). IHC-Fr ; Human . PubMed: 15671068
  • Liu Z  et al. Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus. Proc Natl Acad Sci U S A 98:6104-9 (2001). PubMed: 11353864
  • Chan SL  et al. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem 275:18195-200 (2000). PubMed: 10764737
  • Yamada KA  et al. Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum. J Cardiovasc Pharmacol 36:14-21 (2000). PubMed: 10892655
  • Moore RA  et al. A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and function. J Cell Biol 140:843-51 (1998). PubMed: 9472036
  • Protasi F  et al. Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J Cell Biol 140:831-42 (1998). PubMed: 9472035
  • Liu G & Pessah IN Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls. J Biol Chem 269:33028-34 (1994). PubMed: 7806531
  • Chen SR  et al. Positioning of major tryptic fragments in the Ca2+ release channel (ryanodine receptor) resulting from partial digestion of rabbit skeletal muscle sarcoplasmic reticulum. J Biol Chem 268:22642-9 (1993). PubMed: 8226772
  • Airey JA  et al. Three ryanodine receptor isoforms exist in avian striated muscles. Biochemistry 32:5739-45 (1993). PubMed: 7684927
  • Walton PD  et al. Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons. J Cell Biol 113:1145-57 (1991). PubMed: 1645737
  • Airey JA  et al. Identification and localization of two triad junctional foot protein isoforms in mature avian fast twitch skeletal muscle. J Biol Chem 265:14187-94 (1990). PubMed: 2387846

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