Overview

  • Product name

    Ryngo® 1-23, Dynamin activator
  • Description

    Dynamin activator. Endocytosis inhibitor.
  • Alternative names

    • Bis-T-23
  • Biological description

    Dynamin activator; Stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity. Endocytosis inhibitor; Inhibits transferrin uptake by clathrin-mediated endocytosis in dendritic cells.

  • Purity

    > 97%
  • CAS Number

    171674-76-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2E,2'E)-N,N'-1,3-Propanediylbis[2-cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide
  • Molecular weight

    480.43
  • Molecular formula

    C23H20N4O8
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc2cc(\C=C(/C#N)C(=O)NCCCNC(=O)C(\C#N)=C\c1cc(O)c(O)c(O)c1)cc(O)c2O
  • Source

    Synthetic

References

This product has been referenced in:

  • Gu C  et al. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic 15:819-38 (2014). Read more (PubMed: 24891099) »
  • Sandgren KJ  et al. A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathog 6:e1000866 (2010). Read more (PubMed: 20421949) »

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