• Product name
    (S)-3,5-DHPG, group I mGlu agonist
  • Description
    Selective group I mGlu agonist
  • Biological description
    Selective group I mGlu agonist.

    Also available in simple stock solutions (ab144484) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity
    > 99%
  • CAS Number
  • Chemical structure
    Chemical Structure



Our Abpromise guarantee covers the use of ab120007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.


  • SK-N-SH cells were incubated at 37°C for 30 minutes with vehicle control (0 µM) and different concentrations of (S)-3,5-DHPG (ab120007). Increased expression of CREB (phospho S133) in SK-N-SH cells correlates with an increase (S)-3,5-DHPG concentration, as described in literature.

    Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab32096 at 1/500 dilution and ab32515 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.


This product has been referenced in:
  • Kew JN & Kemp JA Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179:4-29 (2005). Read more (PubMed: 15731895) »
  • Barton ME & Shannon HE Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice. Neuropharmacology 48:779-87 (2005). Read more (PubMed: 15829250) »
  • Wisniewski K & Car H (S)-3,5-DHPG: a review. CNS Drug Rev 8:101-16 (2002). Read more (PubMed: 12070529) »
See all 21 Publications for this product

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A


Merci de nous avoir contactés.

Le laboratoire vient de m'informer que le poids moléculaire donné sur la fiche technique en ligne correspond à la structuredonnée pour ce composé.

La différence observée est due àla présence d'eau et/ou de sels. Ces différences n'affectent en rien l'activité biologique du composé, elles sont néanmoins importantes et doivent être prises en compte pour la reprise en solution. Dans ce cas c'est le poids moléculaire indiqué sur la boite qui doit être utilisé et non le poids moléculaire "théorique" de la fiche technique.

J'espère que ces informations vous seront utiles. N'hésitez pas à nous contacter de nouveau si vous avez d'autres questions.

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The Material Safety Data Sheets (MSDS) for our products that require one are located on the online product datasheet as a PDF file. For this product, ab120007, please see the PDF file at https://www.abcam.com/ps/Products/120/ab120007/Msds/ab120007_WPNA_EN.pdf

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Thank you for contacting us.

I have checked our internal datasheet and verified this product does not require any particular shipping temperature. If it was shipped with other products that needed to be stored at -4C, then blue ice would have been added to the package.

It is however recommended to store it at -20C upon arrival.

All of our products are covered by our Abpromise guarantee; which ensures that you can trust our products, and they should work in the tested species and applications stated on the datasheet, or we will offer a replacement, credit, or refund, if reported within 6 months of purchase.

Please let me know how the antibody performs, and do not hesitate to contact us if it does not do it as expected.

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