S-(5'-Adenosyl)-L-homocysteine, Amino acid derivative (ab144889)

Overview

  • Product name

    S-(5'-Adenosyl)-L-homocysteine, Amino acid derivative
  • Description

    Amino acid derivative that is an important intermediate in metabolic pathways.
  • Alternative names

    • Adenosyl-L-homocysteine
    • Adenosylhomocysteine
    • AdoHcy
    • L-5’-S-(3-Amino-3-carboxypropyl)-
    • L-S-Adenosylhomocysteine
    • S-(5’-Deoxyadenosin-5’-yl)-L-homocysteine
    • S-Adenosyl-L-homocysteine
    • S-Adenosylhomocysteine
    • SAH
    see all
  • Biological description

    Amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways. Competitive inhibitor (versus AdoMet) of DNA methyltransferases (S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases). Used in a variety of studies on epigenetics in hyperhomocysteinemic states.

  • CAS Number

    979-92-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    L-5’-S-(3-Amino-3-carboxypropyl)-5’-thioadenosine
  • Molecular weight

    384.41
  • Molecular formula

    C14H20N6O5S
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Tehlivets O  et al. S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model system. Biochim Biophys Acta 1832:204-15 (2013). Read more (PubMed: 23017368) »

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