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Neuroscience Neurotransmitter Amino Acids Glutamate
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(S)-AMPA (mM/ml), AMPA agonist (ab144483)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (8)

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Chemical Structure - (S)-AMPA (mM/ml), AMPA agonist (ab144483)
  • Cellular activation - (S)-AMPA (mM/ml), AMPA agonist (ab144483)

Key features and details

  • AMPA agonist. 1 ml water soluble pack.
  • CAS Number: 83643-88-3
  • Purity: > 98%
  • Soluble in 1 ml water to give specified mM/ml concentration
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    (S)-AMPA (mM/ml), AMPA agonist
  • Description

    AMPA agonist. 1 ml water soluble pack.
  • Biological description

    AMPA agonist.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

  • Purity

    > 98%
  • CAS Number

    83643-88-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid
  • Molecular weight

    186.17
  • Molecular formula

    C7H10N2O4
  • PubChem identifier

    158397
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    N[C@@H](Cc1c(C)onc1O)C(=O)O
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Amino Acids
    • Glutamate
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Glutamate Receptors
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • AMPA / Kainate
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • NMDA Receptors
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Ligand-Gated Ion Channels
    • More Channels
    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cytochromes
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    • Neurotransmission
    • Receptors / Channels
    • More Ion Channels
    • Signal Transduction
    • Signaling Pathway
    • G Protein Signaling
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    • Sensory System
    • Somatosensory system
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    • Other
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
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    • Metabolism
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    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipases
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    • Metabolic signaling pathways
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    • Metabolism
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    • Mitochondrial Metabolism
    • Cytochromes
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    • Product Range
    • Stock Solutions

Images

  • Chemical Structure - (S)-AMPA (mM/ml), AMPA agonist (ab144483)
    Chemical Structure - (S)-AMPA (mM/ml), AMPA agonist (ab144483)
    2D chemical structure image of ab144483, (S)-AMPA (mM/ml), AMPA agonist
  • Cellular activation - (S)-AMPA (mM/ml), AMPA agonist (ab144483)
    Cellular activation - (S)-AMPA (mM/ml), AMPA agonist (ab144483)Image from Sims R E, et al. Plos One, 8(1), e53814. Fig 1d,; doi: 10.1371/journal.pone.0053814
    Release of adenosine by evoked after depolarisation with AMPA

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (8)

Publishing research using ab144483? Please let us know so that we can cite the reference in this datasheet.

ab144483 has been referenced in 8 publications.

  • Ye S  et al. Expanding the genetic code in Xenopus laevis oocytes. Chembiochem 14:230-5 (2013). PubMed: 23292655
  • Sims RE  et al. Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study. PLoS One 8:e53814 (2013). PubMed: 23326515
  • Maroto M  et al. Chondroitin sulfate, a major component of the perineuronal net, elicits inward currents, cell depolarization, and calcium transients by acting on AMPA and kainate receptors of hippocampal neurons. J Neurochem : (2013). PubMed: 23350646
  • Kunz PA  et al. Presynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release. J Neurosci 33:7762-9 (2013). PubMed: 23637168
  • Ledonne A  et al. A continuous high frequency stimulation of the subthalamic nucleus determines a suppression of excitatory synaptic transmission in nigral dopaminergic neurons recorded in vitro. Exp Neurol 233:292-302 (2012). PubMed: 22056941
  • Schätzle P  et al. Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA1 pyramidal cells. J Physiol 589:4353-64 (2011). PubMed: 21768266
  • Maltsev AS & Oswald RE Hydrophobic side chain dynamics of a glutamate receptor ligand binding domain. J Biol Chem 285:10154-62 (2010). PubMed: 20110365
  • Ruiz A  et al. Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes. Cell Death Dis 1:e54 (2010). PubMed: 21364659

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