(S)-Cotinine, nicotine metabolite (ab144813)

Overview

  • Product name

    (S)-Cotinine, nicotine metabolite
  • Description

    Major metabolite of nicotine in humans. Activates, and desensitizes neuronal nicotinic acetylcholine receptors.
  • Alternative names

    • (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
    • (S)-(-)-1-Methyl-5-(3-pyridiyl)-2-
    • (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone
    • (S)-Cotinine
    • NIH 10498
    see all
  • Biological description

    Major metabolite of nicotine in humans. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model. Activates a subpopulation of α3/α6β2 nAChRs in monkey striatum.

  • CAS Number

    486-56-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
  • Molecular weight

    176.22
  • Molecular formula

    C10H12N2O
  • Storage instructions

    Store at +4°C.
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Echeverria V  et al. Cotinine reduces amyloid-ß aggregation and improves memory in Alzheimer's disease mice. J Alzheimers Dis 24:817-35 (2011). Read more (PubMed: 21321389) »
  • O'Leary K  et al. Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic receptors in monkey striatum. J Pharmacol Exp Ther 325:646-54 (2008). Read more (PubMed: 18305015) »
  • Terry AV  et al. Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev 11:229-52 (2005). Read more (PubMed: 16389292) »
  • Buccafusco JJ & Terry AV The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci 72:2931-42 (2003). Read more (PubMed: 12706481) »
  • Dwoskin LP  et al. (S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner. J Pharmacol Exp Ther 288:905-11 (1999). Read more (PubMed: 10027825) »

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